Ubiquitination, Biotech Startups, and the Future of TRIM Family Proteins: A TRIM-Endous Opportunity
نویسندگان
چکیده
منابع مشابه
TRIM-NHL Proteins Take on miRNA Regulation
The TRIM-NHL family of proteins is conserved among metazoans and has been shown to regulate cell proliferation and development. In this issue, Hammell et al. (2009) and Schwamborn et al. (2009) identify two members of this protein family, NHL-2 in worms and TRIM32 in mice, as positive regulators of microRNA function.
متن کاملThe Antiviral Spectra of TRIM5α Orthologues and Human TRIM Family Proteins against Lentiviral Production
BACKGROUND Rhesus monkey TRIM5α (TRIM5αrh) recognizes the incoming HIV-1 core through its C-terminal B30.2(PRYSPRY) domain and promotes its premature disassembly or degradation before reverse transcription. Previously, we have shown that TRIM5αrh blocks HIV-1 production through the N-terminal RBCC domain by the recognition of Gag polyproteins. Although all TRIM family proteins have RBCC domains...
متن کاملIntroducing TRIM
We present TRIM, an abstract machine capable of executing a subset of the algebraic speci cation language OBJ3. A speci cally designed compiler translates the order sorted conditional equations of an OBJ3 speci cation into TRIM code. The fact that TRIM supports order sorted term rewriting natively di erentiates it from many other abstract term rewriting machines. To obtain more e cient abstract...
متن کاملOrigin and Evolution of TRIM Proteins: New Insights from the Complete TRIM Repertoire of Zebrafish and Pufferfish
Tripartite motif proteins (TRIM) constitute a large family of proteins containing a RING-Bbox-Coiled Coil motif followed by different C-terminal domains. Involved in ubiquitination, TRIM proteins participate in many cellular processes including antiviral immunity. The TRIM family is ancient and has been greatly diversified in vertebrates and especially in fish. We analyzed the complete sets of ...
متن کاملRegulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins
The innate immune system recognizes microbial components through pattern-recognition receptors (PRRs), including membrane-bound Toll-like receptors and cytosolic receptors such as RIG-I-like receptors and deoxyribonucleic acid (DNA) sensors. These PRRs trigger distinct signal transduction pathways that culminate in induction of an array of cytokines and other mediators required for host defense...
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ژورنال
عنوان ژورنال: Cells
سال: 2021
ISSN: 2073-4409
DOI: 10.3390/cells10051015